The role of insulin receptor substrate 2 in hypothalamic and β cell function
J. Clin. Invest. Agharul I. Choudhury, et al. 115:940 doi:10.1172/JCI24445 [Go to this article.]

Figure 3
Glucose homeostasis in RIPCreIrs2KO, NesCreIrs2KO, and POMCCreIrs2KO mice. (A) Fasting blood glucose levels of 12-week-old male mice of the indicated genotypes were measured after a 16-hour overnight fast. (B). Glucose tolerance tests were performed on 12-week-old male RIPCreIrs2KO (filled squares) and control mice (open squares). (C) Glucose tolerance tests were performed on 12-week-old male NesCreIrs2KO (filled squares) and control mice (open squares). (D) Fasting blood glucose levels of 6-month-old male mice of the indicated genotypes were measured after a 16-hour overnight fast. (E) Fasting blood insulin levels of 12-week-old male mice of the indicated genotypes were measured after a 16-hour overnight fast. Data in A–E represent the mean ± SEM for 8–10 animals of each genotype. (F) We calculated the percentage of the total pancreatic area occupied by β cells in 12-week-old male mice of the indicated genotypes using insulin-stained pancreatic sections. The right side shows data for 9-month-old RIPCreIrs2KO and control mice. Four pancreata were analyzed per genotype at each time point, and for each pancreas, 4 sections were analyzed. The data presented are mean ± SEM for 4 mice of each genotype. *P < 0.05, **P < 0.01, and ***P < 0.001. Cont, control.