Deficits in amygdaloid cAMP-responsive element–binding protein signaling play a role in genetic predisposition to anxiety and alcoholism
J. Clin. Invest. Subhash C. Pandey, et al. 115:2762 doi:10.1172/JCI24381 [Go to this article.]

Figure 6
The effect of PKA activator infusion into the CeA on ethanol intake and anxiety-like behaviors in P rats. Upper panel: The alcohol-drinking patterns (7 and 9% ethanol) and the effect of Sp-cAMP infusion into the CeA on alcohol intake (last 3 days of 9% ethanol intake) in P rats. Values represent the mean ± SEM of 5–6 rats in each group. Lower panel: The effect of PKA activator infusion (0.5 μl of 80 nmol of Sp-cAMP or aCSF once daily for 3 days) and ethanol exposure on open- and closed-arm activities of P rats in the EPM. Values represent the mean ± SEM of 5–6 rats in each group. ^#P < 0.01, *P < 0.001 versus P rats infused with aCSF.