Deficits in amygdaloid cAMP-responsive element–binding protein signaling
play a role in genetic predisposition
to anxiety and alcoholism
J. Clin. Invest. Subhash C. Pandey, et al. 115:2762 doi:10.1172/JCI24381 [
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Figure 1Alcohol-drinking patterns and anxiety-like behaviors in P and NP rats. Upper panel: Ethanol intake (7% for 3 days, 10% for 3 days, and 12% for 3 days) was measured by the 2-bottle free choice paradigm in P and NP rats. Values represent the mean ± SEM of 6 rats in each group. Lower panel: The effects of voluntary ethanol intake on open- and closed-arm activities of P and NP rats in the EPM test. Values represent the mean ± SEM of 5–6 rats in each group. *
P < 0.001 versus respective controls.
