Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion
J. Clin. Invest. Marie Fischer, et al. 116:2748 doi:10.1172/JCI24274 [Go to this article.]

Figure 5
Signaling downstream CD30L involves MAPK and PI3K pathways in CBMCs. (A) CBMCs were activated with CD30-Fc or CD6-Fc for 15 and 30 minutes, and phosphorylation of ERK (1/2) was measured by Western blot. (B) Effects of p38 inhibitor SB203580 (SB), MEK inhibitor PD98059 (PD), and PI3K inhibitors Wortmannin (Wort) and LY294002 (LY) on IL-8 secretion upon CD30-Fc treatment were analyzed by ELISA. Results are presented as percentage of control (no inhibitor) ± SEM, n = 3.