Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion
J. Clin. Invest. Marie Fischer, et al. 116:2748 doi:10.1172/JCI24274 [
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Figure 4Induced IL-8 secretion is due to de novo synthesis. Levels of IL-8 present in supernatants from CBMCs (1 × 10
5 cells/ml) after 24 hours treatment with CD30-Fc (10 μg/ml). Stimulation was conducted with or without the presence of the protein synthesis inhibitor cycloheximide (CHX) (50 μM).
