Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion
J. Clin. Invest. Marie Fischer, et al. 116:2748 doi:10.1172/JCI24274 [Go to this article.]

Figure 3
CD30-Fc induces IL-8 secretion in a time- and dose-dependent manner. (A) Amount of IL-8 present in supernatant 24 hours after activation of CBMCs (1 × 10⁵ cells/ml) with different concentrations of CD30-Fc (0, 0.1, 1, 10, and 50 μg/ml). (B) Kinetics of IL-8 secretion in response to 10 μg/ml of CD30-Fc was measured at 4 different time points (2, 4, 8, and 24 hours). (C) Spontaneous release of IL-8 from untreated CBMCs compared with CD30-Fc–treated cells. Data presented were derived from a single representative experiment out of 3 performed.