Toru Aizawa, Mitsuhisa Komatsu
J Clin Invest.
2005;
115(2):227–230
doi:10.1172/JCI24269
This article Copyright © 2005, The American Society for Clinical Investigation
Abstract
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I
n pancreatic β cells, not only insulin exocytosis per se, but translocation of β granules toward the plasma membrane — an event upstream of exocytosis — are under the control of glucose. However, the molecular basis of this translocation has been poorly understood. Rab27a-mediated translocation of glucose-induced β granules is reported in this issue of the JCI. Rab27a or its effector molecule may constitute a novel pharmacological target because potentiation of the Rab27a pathway is expected to restore β cell glucose competency in patients with diabetes mellitus.
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