Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure
J. Clin. Invest. Jianchao Xu, et al. 115:1275
doi:10.1172/JCI24066 [Go to this article.]

Figure 1
Tissue expression of renalase. (A) Northern blot analysis of human tissues using the MGC12474 clone as a probe. The upper band in skeletal muscle and lower bands in kidney and liver may represent alternatively spliced forms of renalase. (B) Western blot analysis of rat tissues using a renalase polyclonal antibody. (CF) Renalase expression in kidney. (C) In situ hybridization analysis of human kidney. Left: antisense probe. Open arrow indicates the glomerulus; filled arrow indicates proximal tubules. Scale bar: 40 μm. Right: sense probe control. Magnification, ×200. (D) Immunolocalization in human kidney. Left: anti-renalase antibody. Filled arrow indicates proximal tubules. Scale bar: 40 μm. Right: preimmune serum. Magnification, ×630. (E) Immunofluorescence in human kidney. Left panels: anti-renalase antibody, thick arrow denotes the glomerulus; thin arrows indicate proximal tubules. Right panels: preimmune serum. Scale bars: 40 μm. (F and G) Renalase expression in heart. (F) In situ hybridization analysis of human heart. Left: antisense probe. Open arrow indicates blood vessels; filled arrow indicates ventricular myocytes. Scale bar: 40 μm. Right: sense probe control. Magnification, ×200. (G) Immunolocalization in human heart. Left: anti-renalase antibody. Open arrow indicates blood vessels; filled arrows indicate ventricular myocytes. Scale bar: 40 μm. Right: preimmune serum. Magnification, ×630.