Shao-Nian Yang, Per-Olof Berggren
J Clin Invest.
2005;
115(1):16–20
doi:10.1172/JCI23970
This article Copyright © 2005, The American Society for Clinical Investigation
Abstract
|
Full text
|
PDF
I
nsulin secretion is critically dependent on the proper function of a complex molecular network. CaV2.3-knockout (CaV2.3–/–) and PKCλ-knockout (PKCλ–/–) mouse models now suggest that these 2 players, the Cav2.3 channel and PKCλ, are important constituents of this molecular network. Subsequent to glucose stimulation, insulin is released from the pancreatic β cell in a biphasic pattern, i.e., a rapid initial phase followed by a slower, more sustained phase. Interestingly, Ca2+ influx through the CaV2.3 channel regulates only the second phase of insulin secretion. PKCλ seems to enter the β cell nucleus and in turn modulates the expression of several genes critical for β cell secretory function. Studies by Hashimoto et al. and Jing et al. in this issue of the JCI set out to answer the question of why numerous isoforms of proteins with similar functions are present in the β cell. This is important, since it has been difficult to understand the modulatory and/or regulatory roles of different isoforms of proteins in defined subcellular compartments and at various times during the secretory process in both β cell physiology and pathophysiology.
This file is in Adobe Acrobat (PDF) format.
If you have not installed and configured the Adobe Acrobat Reader on your system.
Having trouble reading a PDF?
PDFs are designed to be printed out and read, but if you prefer to read them online, you may find it easier if you increase the view size to 125%.
Having trouble saving a PDF?
Many versions of the free Acrobat Reader do not
allow Save. You must instead save the PDF from the JCI Online page you downloaded it from. PC users:
Right-click on the Download link and choose the option that says something like "Save Link As...".
Mac users should hold the mouse button down on the link to get these same options.
Having trouble printing a PDF?
- Try printing one page at a time or to a newer printer.
- Try saving the file to disk before printing rather than opening it "on the fly." This requires that you
configure your browser to "Save" rather than "Launch Application" for the file type "application/pdf", and can
usually be done in the "Helper Applications" options.
- Make sure you are using the latest version of Adobe's Acrobat Reader.
