Regeneration of the pancreatic β cell
J. Clin. Invest. Massimo Trucco, et al. 115:5 doi:10.1172/JCI23935 [
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Figure 3Using a GFP-transgenic mouse as donor, it is possible to observe how the majority of the transplanted bone marrow cells do not directly participate in the regeneration of the endogenous pancreas. As shown here, there are no double-positive (orange) cells in the newly formed islets. The donor cells (green) appear to be located close to possibly existing juxta-ductal precursor cells, which may be activated by bone marrow cell–secreted factors. Insulin-positive cells are red. Magnification, ×400. See also refs.
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