The matrix component biglycan
is proinflammatory and signals through
Toll-like receptors 4 and 2 in macrophages
J. Clin. Invest. Liliana Schaefer, et al. 115:2223 doi:10.1172/JCI23755 [
Go to this article.]
Figure 1Bgn
deficiency improved survival and lowered plasma levels of TNF α in mice with LPS-induced sepsis. (
A and
C) Survival of male
Bgn–/0
and
Bgn+/0
mice (
n
= 6) (
A) and female
Bgn+/+
,
Bgn+/–
, and
Bgn–/–
mice (
n
= 7) (
C) after a lethal dose of LPS. Two of the
Bgn–/– mice survived. (
B and
D) Plasma levels of TNF-α in male control mice without LPS (
Bgn+/0 and
Bgn–/0, each group
n = 3) and in
Bgn+/0 (
n = 5) and
Bgn–/0 mice (
n = 4) 90 minutes after a sublethal dose of LPS (
B) and in female control
Bgn+/+ mice without LPS and in
Bgn+/+,
Bgn+/–, and
Bgn–/– mice (each group
n = 3) 90 minutes after a sublethal dose of LPS (
D). Data are given as means ± SD. *
P < 0.05.
