Antonio Castrillo, Peter Tontonoz
J Clin Invest.
2004;
114(11):1538–1540
doi:10.1172/JCI23705
This article Copyright © 2004, The American Society for Clinical Investigation
Abstract
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C
ardiovascular disease is the leading cause of morbidity and mortality in Western countries. Previous studies have highlighted the beneficial effects of PPARγ activators on cardiovascular disease; however, the role of other PPAR family members in atherosclerosis is less clear. A report in this issue of the JCI expands our understanding of PPARs in vascular biology and highlights the potential use of multiple PPAR agonists to limit lipid accumulation in macrophages.
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