An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression
J. Clin. Invest. Michael Niedermaier, et al. 115:900 doi:10.1172/JCI23675 [
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Figure 3Sequence conservation at the Shh locus. Results of sequence alignments using MultiPIPMaker and mVISTA programs are summarized; red bars reflect high conservation between species. Four CNEs could be identified (CNE1–CNE4) that are highly conserved throughout the human, chick, and F. rubripes (Fugu) genomes. MultiPIPMaker plots of CNE1–CNE4 show regions of significant similarity between species as indicated by horizontal lines.
