An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression
J. Clin. Invest. Michael Niedermaier, et al. 115:900 doi:10.1172/JCI23675 [Go to this article.]

Figure 1
Dsh/Dsh a regulatory mutation of Shh. (A) Phenotype of E17.5 embryos. Alizarin red/alcian blue–stained skeletal preparations below. Dsh/Dsh, Dsh/+;Shh^+/–, and Shh^–/– embryos show a nearly identical phenotype. (B) Quantitative RT-PCR from WT and Dsh/Dsh RNA samples obtained from E10.5, E11.5, E12.5, and E13.5 embryos. Bars represent levels (± SD) of Shh expression relative to WT E10.5.