GPR109A (PUMA-G/HM74A) mediates nicotinic acid–induced flushing
J. Clin. Invest. Zoltán Benyó, et al. 115:3634 doi:10.1172/JCI23626 [
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Figure 4PUMA-G mediates the flushing response to NA. (
A–
D) Original recordings of the LDF response to i.p. injection of 200 mg/kg NA (
A–
C) or 2 mg/kg PGD
2 (
D) in PUMA-G
+/+ (
A), PUMA-G
+/– (
B), and PUMA-G
–/– (
C and
D) mice. (
E) Quantitative analysis of the percentage of LDF increase after administration of NA in PUMA-G
+/+ (white bars,
n = 8), PUMA-G
+/– (gray bars,
n = 10), and PUMA-G
–/– (black bars,
n = 10) mice. ***
P < 0.001 vs. PUMA-G
+/+ littermate controls.
