GPR109A (PUMA-G/HM74A) mediates nicotinic acid–induced flushing
J. Clin. Invest. Zoltán Benyó, et al. 115:3634 doi:10.1172/JCI23626 [Go to this article.]

Figure 3
NA-induced flushing involves EP₂, EP₄, and DP but not IP. (A–D) Original recordings of the flushing response to nicotinic acid (200 mg/kg i.p.) in DP^–/– (A), EP₂^–/– (B), EP₄^–/– (C), and IP^–/– mice (D). (E) Quantitative analysis of the percentage of LDF increase in response to NA in wild-type control animals (n = 27) and the indicated mutants (n = 6–15). *P = 0.013; ***P < 0.001 vs. control (contr.).