GPR109A (PUMA-G/HM74A) mediates nicotinic acid–induced flushing
J. Clin. Invest. Zoltán Benyó, et al. 115:3634 doi:10.1172/JCI23626 [
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Figure 2COX-1 but not eNOS is required for NA-induced flushing. (
A–
C) Original LDF recordings (
A and
B) and quantitative analysis of the percentage of LDF increase (
C) after i.p. administration of 200 mg/kg NA indicate normal first and second peaks of the flushing response in eNOS
–/– mice (
B and
C, black bars,
n = 9) compared with wild-type littermate controls (
A and
C, white bars,
n = 9). (
D–
F) Original LDF recordings (
D and
E) and quantitative analysis of the percentage of LDF increase (
F) after administration of NA to COX-1
–/– mice (
E and
F, black bars,
n = 7) and wild-type littermates (
D and
F, white bars,
n = 6). **
P = 0.002, ***
P < 0.001 vs. COX-1
+/+.
