Do DNA sequence variants in ABCA1 contribute to HDL cholesterol levels in the general population?
J. Clin. Invest. Päivi Pajukanta, et al. 114:1244 doi:10.1172/JCI23466 [Go to this article.]

Figure 1
A schematic overview of the role of the ABCA1 protein in HDL metabolism and RCT. In RCT, excess free cholesterol (FC) is removed from peripheral tissues and returned to the liver for excretion in the bile. The ABCA1 protein is crucial for the initial steps of this process, since it controls the efflux of intracellular cholesterol to lipid-poor apoAI, which is the major apolipoprotein of HDL. The other key molecules in RCT include LCAT and scavenger receptor class-B, type I (SR-BI). CE, cholesteryl ester.