Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer
J. Clin. Invest. Raffaele Ciampi, et al. 115:94 doi:10.1172/JCI23237 [
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Figure 1Identification of the
BRAF gene rearrangement. (
A) Genomic region on 7q containing the
BRAF gene and position of PAC clones used as a probe for FISH. (
B) Interphase nucleus from the index tumor showing split of 1
BRAF signal (red) and preservation of 2 chromosome 7 centromeric signals (green), which indicates the rearrangement of the
BRAF gene.
