Induction of prolonged survival of CD4⁺ T lymphocytes by intermittent IL-2 therapy in HIV-infected patients
J. Clin. Invest. Joseph A. Kovacs, et al. 115:2139 doi:10.1172/JCI23196 [Go to this article.]

Figure 5
Deuterium labeling kinetics in naive (CD27⁺CD45RO^–) cells in patients receiving IL-2. The left panels show the measured data (symbols) and the fitting by the model equations (solid lines) for patients 3, 5, and 6 following an early cycle (blue) and a later cycle (red), and for patients 1 and 2 following the single late IL-2 cycle; the right panels show the probability density function of the normal distribution of log d multiplied by the total source of labeled cells (S). Mean log decay m_d values for these data are (early/late): –1.16/–2.52, –1.35/–2.61, and –1.49/–2.14 for patients 3, 5, and 6, respectively (P = 0.039 for early vs. late, Student’s t test), and –2.72 and –3.52 for patients 1 and 2, respectively. No significant change was seen in the mean log decay m_d for the other CD4 subsets or for any of the CD8 subsets for patients 3, 5, and 6. Average values for mean log decay m_d for these subsets were as follows (early/late): CD4 central memory (CD27⁺CD45RO⁺), –0.54/–0.70; CD4 effector memory (CD27^–CD45RO⁺), –0.59/–0.74; CD8 naive (CD27⁺CD45RO^–), –1.00/–1.90; CD8 central memory (CD27⁺CD45RO⁺), –0.82/–1.26; CD8 effector memory (CD27^–CD45RO⁺), –0.19/–0.36; CD8 effector memory (CD27^–CD45RO^–), –1.02/–1.13.