Induction of prolonged survival of CD4⁺ T lymphocytes by intermittent IL-2 therapy in HIV-infected patients
J. Clin. Invest. Joseph A. Kovacs, et al. 115:2139 doi:10.1172/JCI23196 [Go to this article.]

Figure 3
Slower decay of deuterium labeling in CD4 but not CD8 cells after later cycles of IL-2. (A and C) Mean log decay shifted to the left for CD4 cells (A) but not CD8 cells (C) in 5 of 6 patients, indicating a longer average survival of CD4 cells (but not CD8 cells) following later IL-2 cycles (3 to 6) compared to earlier cycles (1 to 3). Patient 3 had an infusion of ²H-glucose before beginning IL-2 therapy (green diamonds), and patient 5 received a third infusion during his fourth IL-2 cycle (purple circles). The solid lines represent the fitting by the model equations. (B and D) The probability density function of the normal distribution of log d multiplied by the total source of labeled cells (S). Mean log decay rate constants for CD4/CD8 cells for the patients are, respectively: pt. 3, –0.59/0.06 (no IL-2), –0.33/–0.91 (cycle 1), –1.79/–0.68 (cycle 6); pt. 5, –1.03/–0.95 (cycle 1), –1.80/–1.30 (cycle 3), –1.86/–1.39 (cycle 4); pt. 6, –0.09/–2.05 (cycle 2), –1.73/–2.19 (cycle 4); pt. 7, –0.45/–1.01 (cycle 2), –0.94/–1.07 (cycle 5); pt. 8, –1.07/–2.18 (cycle 3), –2.30/–2.20 (cycle 4); pt. 10, –1.14/–0.95 (cycle 1), –0.66/–0.92 (cycle 3).