Qa-1 restriction of CD8⁺ suppressor T cells
J. Clin. Invest. Stefanie Sarantopoulos, et al. 114:1218 doi:10.1172/JCI23152 [Go to this article.]

Figure 1
Engagement of Qa-1 by the TCR and by CD94/NKG2A. (A) Presentation of Qa-1–bacterial GroEL peptide by a DC following Salmonella infection to CD8⁺ T cells, where the receptor is a TCR, leads to CTL responses. (B) Presentation of Qa-1–self peptides by activated CD4⁺ T cells to CD8⁺ T cells, where the receptor is a TCR, leads to the development of Qa-1–restricted suppressor CD8⁺ T cells. (C) Engagement of CD94/NKG2A receptors on CD8⁺ T cells with a DC can inhibit either TCR-mediated CTL responses specific for Qa-1–foreign peptide ligands and/or TCR-mediated suppressive responses specific for Qa-1–self peptide ligands. This NKG2A-dependent interaction may regulate expression of suppressor or cytotoxic CD8⁺ T cells through inhibition of cellular activation or diminished AICD.