Eva Szomolanyi-Tsuda, Raymond M. Welsh
J Clin Invest.
2004;
114(7):895–897
doi:10.1172/JCI23098
This article Copyright © 2004, The American Society for Clinical Investigation
Abstract
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T
he production of protective neutralizing antibodies occurs quickly in some viral infections but very slowly in others. In a new study, surface glycoproteins (the targets of neutralization) of 2 different viruses were genetically switched. Analysis of the neutralizing antibody response to each of the 2 parent and recombinant viruses in infected mice revealed that the speed of neutralizing antibody induction was intrinsically dependent on the surface glycoprotein and not the rest of the virus.
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