Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor
J. Clin. Invest. Joel G.R. Weaver, et al. 115:1828 doi:10.1172/JCI22954 [
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Figure 5Effects of NFV on apoptosis in yeast. (
A) WT yeast or yeast deficient in both isoforms of VDAC (VDAC Δ1 and Δ2) or 3 isoforms of ANT (ANT Δ1, Δ2, and Δ3) were treated with the apoptosis-inducing agents Vpr peptide (residues 52–96) or H
2O
2 and analyzed for viability. (
B) WT yeast treated with varying doses of NFV was treated with the same apoptosis inducers and analyzed for viability. Results are representative of 3 independent experiments. *
P < 0.05.
