Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor
J. Clin. Invest. Joel G.R. Weaver, et al. 115:1828 doi:10.1172/JCI22954 [
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Figure 1Effects of NFV/RIT on Jo-2–induced hepatitis or SEB-induced shock. (
A) Mice treated with varying doses of Jo-2 antibody in the presence or absence of NFV/RIT were followed for 30 days and analyzed for survival. (
B) In parallel, mice treated in a similar manner were sacrificed at 4 or 24 hours and analyzed for serum AST level. *
P < 0.05. (
C) Five mice per group were treated with SEB/D-gal with or without NFV/RIT before or 4 hours after SEB or with NFV alone or RIT alone before SEB. Twenty-four-hour survival was monitored (cumulative data from 4 independent experiments are shown). (
D) Mice treated with SEB/D-gal with NFV/RIT or control were analyzed for V-β8 T cell apoptosis by TUNEL assay (cumulative data from 4 independent experiments are shown).
#P < 0.01.
