Depletion of CD8 lymphocytes in SIV-infected rhesus macaques by administration of mAb cM-T807. Absolute number of CD3⁺CD4⁺ and CD3⁺CD8⁺ T lymphocytes from SIVmac251-infected, CD8 lymphocyte–depleted rhesus macaques. Data presented are for 6 SIV-infected, CD8 lymphocyte–depleted animals. Open symbols represent 4 animals that developed AIDS with SIVE. Filled symbols represent animals that received CART beginning on day 28 after infection. Day 0 represents the time of SIVmac251 infection. All animals were persistently CD8⁺ T lymphocyte depleted (>28 days).