Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation
J. Clin. Invest. Saori Nishio, et al. 115:910 doi:10.1172/JCI22850 [Go to this article.]

Figure 7
Signaling pathways related to proliferation or apoptosis in cyst epithelial cells. (A) Expression of signal transducers in the kidneys of Pkd1^–/– mice at E16.5 and Pkd1^–/–/LZ⁺ mice 1 month of age was analyzed using Western blot. Actin was used as a loading control for protein. Data presented are 1 representative of 4 independent experiments. (B) A kidney from a P8 Pkd1^–/–/LZ⁺ mouse was stained with anti–p-ERK, anti–p-JNK, or anti–p-Akt. The same section was stained with β-gal and counterstained with Nuclear Fast Red. Black and white arrowheads indicate the same epithelial cells. Original magnification, ×400.