Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation
J. Clin. Invest. Saori Nishio, et al. 115:910 doi:10.1172/JCI22850 [Go to this article.]

Figure 4
Dedifferentiation of Pkd1^–/– cyst epithelial cells. (A–D) A kidney from a P8 Pkd1^–/–/LZ⁺ mouse was stained with anti–polycystin-2 (red, polycystin-2; blue, DAPI) (A), anti–acetylated tubulin (red, acetylated tubulin; green, β-gal; blue, DAPI) (B), anti-DBA (C) or anti–Na-K ATPase (D). (Right panels: A, C, and D) The same section was stained with β-gal and counterstained with Nuclear Fast Red. White and black arrowheads indicate the same epithelial cells. Original magnification, ×400. (B) Left and right panels indicate stainings in cuboidal and flat cyst epithelia, respectively. (E) Relationship between cell height and Na-K ATPase expression in the cyst epithelial cells shown in D. Each symbol indicates a cyst epithelial cell (Pkd1^–/–/LZ⁺) or normal tubular epithelial cell (WT).