Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation
J. Clin. Invest. Saori Nishio, et al. 115:910 doi:10.1172/JCI22850 [Go to this article.]

Figure 3
Histochemical analysis of Pkd1^–/–/LZ⁺ kidneys. Kidneys of Pkd1^–/–/LZ⁺ mice were stained with β-gal and counterstained with Nuclear Fast Red. (A) Kidneys of Pkd1^–/–/LZ⁺ mice with the low chimeric rate at P1, P17, and P30. At the early stage (P1), cyst epithelia were composed of Pkd1^–/– (LZ^–) and LZ⁺ cells. At the late stage (P30), individual cysts were enlarged and most cyst epithelia were composed of Pkd1^–/– (LZ^–) cells. Original magnification, ×200. (B) Kidney of a P3 Pkd1^–/–/LZ⁺ mouse with the intermediate chimeric rate. At the early stage of cystogenesis, both Pkd1^–/– (LZ^–) and LZ⁺ cyst epithelial cells are cuboidal in shape. Original magnification, ×400. (C) Kidney of a P8 Pkd1^–/–/LZ⁺ mouse with the low chimeric rate. Cyst epithelia are composed of flat Pkd1^–/– (LZ^–) cells and cuboidal LZ⁺ cells. Pkd1^–/– (LZ^–) cyst epithelial cells changed their shape from cuboidal to flat. Original magnification, ×200.