Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS
J. Clin. Invest. Luisa M. Villar, et al. 115:187 doi:10.1172/JCI22833 [Go to this article.]

Figure 5
Probability of remaining free of a second relapse, which was evaluated by a Kaplan-Meier test in 48 MS patients that had undergone lumbar puncture after the first attack of the disease. First, the disease course in the 22 patients with OCMBs was compared with that of the 26 patients without them (A). Secondly, the disease course in the 15 patients with LS-OCMBs (LS-OCMB+) was compared with that of the group formed by the 26 patients without OCMBs plus the 7 patients with OCMBs that did not recognize myelin lipids (LS-OCMB–) (B).