Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS
J. Clin. Invest. Luisa M. Villar, et al. 115:187 doi:10.1172/JCI22833 [Go to this article.]

Figure 4
Inhibition of IgM binding to lipid-coated membranes. Four aliquots of CSF from a patient presenting OCMB against PC were analyzed by IEF. Proteins were transferred to: an uncoated nitrocellulose membrane (1), a PC-coated nitrocellulose membrane (2), a PC-coated nitrocellulose membrane embedded with a solution of PC that inhibits binding of specific IgM to the antigen-coated membrane (3), and a PC-coated nitrocellulose membrane embedded with a solution of gangliosides that does not produce any inhibition (4).