Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS
J. Clin. Invest. Luisa M. Villar, et al. 115:187 doi:10.1172/JCI22833 [Go to this article.]

Figure 3
Study of OCMB specificity. The presence of total IgM bands (T) and of oligoclonal IgM reacting against PC, phosphatidylethanolamine (PEA), phosphatidylinositol (PI), phosphatidylserine (PS), sphingomyelin (SP), gangliosides (GA), sulphatides (SU), and membranes coated with Polypep (NC, negative control) were studied in paired serum (S) and CSF (C) samples from 53 MS patients with OCMBs restricted to CSF as determined by IEF and immunodetection. Shown are representative examples of the 4 patterns that were found. (A) OCMBs against PC were detected. (B) OCMBs against PC, PEA, PI, and SP can be observed. (C) OCMBs recognizing SP were found. (D) The OCMBs did not recognize any of the lipids studied.