Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS
J. Clin. Invest. Luisa M. Villar, et al. 115:187 doi:10.1172/JCI22833 [Go to this article.]

Figure 1
Study of B cells in CSF of MS patients with and without OCMBs. (A) Both M+ MS and M– MS OCMBs showed a higher percentage of CD19⁺ cells in CSF when compared with the control group (P < 0.0001). In addition, M+ MS patients show a higher percentage of CD19⁺ cells when compared with M– MS patients (P = 0.0005). (B) Representative dot plots showing CD19⁺ cells present in CSF of an M+ MS patient (left), an M– MS patient (center), and a patient from the control group (right). CD19-PerCP-Cy5.5, CD19–peridinin-chlorophyll-protein–Cy-Chrome 5.5.