Can antibodies with specificity for soluble antigens mimic the therapeutic effects of intravenous IgG in the treatment of autoimmune disease?
J. Clin. Invest. Vinayakumar Siragam, et al. 115:155 doi:10.1172/JCI22753 [Go to this article.]

Figure 7
Antibodies to murine albumin ameliorate K/BxN serum–induced inflammatory arthritis. (A) Ankle width and (B) overall arthritis score following induction of arthritis by injection with K/BxN serum. C57BL/6 mice were injected on day 0 with K/BxN serum (open circles), IVIg + K/BxN serum (open squares), anti-albumin + K/BxN serum (filled triangles), or control IgG + K/BxN serum (filled diamonds) or left untreated (open triangles). ^#P < 0.001, **P < 0.01, *P < 0.05, anti-albumin vs. control IgG. Data represented as the mean ± SEM; n = 3 from 2 independent experiments (with serum and with IVIg + serum); n = 4 from 3 independent experiments (untreated and treated with control IgG + serum and anti-albumin + serum). (C) Hind limbs of representative C57BL/6 mice at day 9 after serum injection.