Can antibodies with specificity for soluble antigens mimic the therapeutic effects of intravenous IgG in the treatment of autoimmune disease?
J. Clin. Invest. Vinayakumar Siragam, et al. 115:155 doi:10.1172/JCI22753 [Go to this article.]

Figure 6
Antibodies to endogenous soluble antigens ameliorate ITP. Thrombocytopenia was induced and platelets counted as described in Figure 4. On day 2 (downward-pointing arrow), CD1 mice were treated (A) intraperitoneally with 50 mg IVIg only (open squares), 1 mg OVA (open circles), or 10 mg OVA (open triangles), followed 4 hours later by 1 mg anti-OVA intravenously; (B) intraperitoneally with 50 mg IVIg (open squares) or intravenously with 1 mg anti-albumin antibody (filled triangles), 1 mg anti-transferrin antibody (open circles), or 1 mg control IgG (filled diamonds); n = 6 mice for each group from 2 independent experiments. ^#P < 0.001, **P < 0.01, treatment vs. control IgG. Data are presented as mean ± SEM.