Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
J. Clin. Invest. Jeremy S. Duffield, et al. 115:56 doi:10.1172/JCI22675 [Go to this article.]

Figure 3
The effect of DT treatment on SAMs in CD11b-DTR mouse liver at peak fibrosis and after 7 days of spontaneous recovery. (A–D) Photomicrographs (magnification, ×400) showing (A) macrophages (Mφ) associated with areas of scarring after 12 weeks of CCl₄-induced injury; (B) absence of macrophages in an area of scarring at 12 weeks of CCl₄ injury, following 5 days of macrophage depletion; (C) macrophages associated with resolving fibrotic band, at 7 days of recovery from CCl₄ injury; and (D) absence of macrophages in scar following macrophage depletion during spontaneous recovery. (E and F) Area of macrophage in fibrotic bands (E) at peak fibrosis following treatment with i.v. PBS, i.p. DT or i.v. DT, or (F) after 7 days of spontaneous recovery after treatment with i.v. PBS, i.p. DT, or i.v. DT (**P < 0.01).