CaV2.3 calcium channels control second-phase insulin release
J. Clin. Invest. Xingjun Jing, et al. 115:146 doi:10.1172/JCI22518 [
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Figure 3Ca
2+ homeostasis in WT and
CaV2.3–/– islets. (
A) [Ca
2+]i in an intact WT
CaV2.3+/+ islet assayed by ratiometric fura-2 measurements. The islets were stimulated at the time points indicated by the arrows in the continued presence of previously added stimuli. (
B) [Ca
2+]i was determined as in
A, but the experiment was performed in an intact
CaV2.3–/– islet. Recordings selected for display are representative of 7 and 9 separate experiments in WT and
CaV2.3–/– islets, respectively. Statistical significances are provided in the text.
