Age-dependent incidence, time course, and consequences of thymic renewal in adults
J. Clin. Invest. Frances T. Hakim, et al. 115:930 doi:10.1172/JCI22492 [Go to this article.]

Figure 3
Effect of age on recovery of naive CD4⁺ T cells after APBSCT. (A) Scatterplot of patient naive (CD45RA⁺CD62L⁺) CD4⁺ T cells after APBSCT. Naive CD4⁺ T cells were reduced substantially by the transplant conditioning regimen and recovered slowly over the next 2 years. Each filled circle represents a single patient value; the red line represents the median and the gray area represents the normal range in adults. Pre, pretreatment; 0, time of transplant. (B) Spearman nonparametric correlation demonstrates that number of naive (CD45RA⁺CD62L⁺) CD4⁺ T cells achieved after approximately 2 years (21–24 months) is dependent on age at time of treatment. (C) Line plots of recovery of naive CD4⁺ T cells in individual patients, stratified by age, during the first 2 years after transplant. The red lines represent patients with thymic enlargement (Figure 2B); the black lines represent those with no evident enlargement.