Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics
J. Clin. Invest. Leo Kager, et al. 115:110 doi:10.1172/JCI22477 [Go to this article.]

Figure 4
Correlation in mRNA expression levels in ALL cells between DHFR and TYMS, and between TYMS and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1). Data are shown for ALL cells from 197 patients. P values are from Pearson correlation. BHD subtypes (n = 42) are depicted in red, BNHD (n = 58) in blue, E2A-PBX1 (n = 21) in yellow, T-ALL (n = 35) in black, and TEL-AML1 (n = 41) in green.