Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction
J. Clin. Invest. Young-sup Yoon, et al. 115:326 doi:10.1172/JCI22326 [
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Figure 4Transplantation of hBMSCs improves cardiac function, increases capillary and CMC density, and decreases myocardial fibrosis in a rat model of MI. (
A–
D) Echocardiographic parameters 4 weeks after MI and cell transplantation show smaller LVEDD and LVESD, better fractional shortening (FS), and lower WMSI in the hBMSC-transplanted rats than in the TBMC- and PBS-treated rats, indicating improved cardiac function. (
E and
F) Invasive hemodynamic measurements using a Millar Instruments Inc. catheter 4 weeks after hBMSC transplantation. LV systolic pressure (LVSP) (
E) and +dP/dt
max and –dP/dt
max (dP/dt
min) (
F) were significantly augmented in the hBMSC-transplanted rats compared with the control groups. LVEDP, LV end-diastolic pressure. *
P < 0.05, **
P < 0.01. (
G and
H) Capillary (
G) and CMC (
H) density measured after CD31 and H&E staining, respectively, was significantly higher in hBMSC-transplanted hearts than in TBMC- and PBS-treated hearts. **
P < 0.01 vs. TBMC and PBS. (
I) Percentage circumferential fibrosis measured in Masson’s trichrome–stained sections was significantly smaller in hBMSC-transplanted hearts. **
P < 0.01 vs. TBMC and PBS.
