Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell–driven B cell responses
J. Clin. Invest. Hyung W. Lim, et al. 114:1640 doi:10.1172/JCI22325 [
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Figure 8CD4
+CD25
+CD69
– Tregs suppress CXCL13 production by CD57
+ GC-Th cells. Equal numbers (10
5 cells) of tonsil CD19
+ B cells, CD57
+ GC-Th cells, and/or CD4
+CD25
+CD69
– Tregs were cultured together for 5 days in the presence of staphylococcal enterotoxin B. The concentrations of CXCL13 protein were measured by ELISA. One set of representative data from 4 independent experiments is shown. UD, undetectable.