JCI - Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice

Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice
J. Clin. Invest. 115:3 doi:10.1172/JCI22304 [Go to this article.]

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Figure 2

Macroscopic and microscopic views of MI with LV myocardial rupture in the dead, vehicle-treated WT mice on day 3 after MI. Note that spontaneous rupture is generated in the LV infarct border near the right ventricle (arrows in A and rectangular area in B). (C) High-power view of the rectangular area in B, showing the rupture (arrows). The black string visible in A is a silk suture used for ligation. Scale bars: 500 μm in B and 100 μm in C.