Jeffrey C. Murray, Brian C. Schutte
J Clin Invest.
2004;
113(12):1676–1678
doi:10.1172/JCI22154
This article Copyright © 2004, The American Society for Clinical Investigation
Abstract
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left lip and palate is a common human birth defect, and its causes are being dissected through studies of human populations and through the use of animal models. Mouse models in particular have made a substantial contribution to our understanding of the gene pathways involved in palate development and the nature of signaling molecules that act in a tissue-specific manner at critical stages of embryogenesis. Related work has provided further support for investigating the role of common environmental triggers as causal covariates.
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