Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy
J. Clin. Invest. Ilona Hauber, et al. 115:76 doi:10.1172/JCI21949 [Go to this article.]

Figure 2
Inhibition of macrophage-tropic (M-tropic) and T cell–tropic (T-tropic) HIV-1. PM1 cells were infected with HIV-1 BaL or NL4/3. Infected cells were cultured in the presence of the indicated concentrations of CNI-1493, or with DMSO alone (control). The culture medium was changed at days 3, 6, and 9. p24 antigen levels and cell viability were determined at days 6 and 12. The percentage of inhibition of virus replication as compared with replication in the control culture without drug, which was arbitrarily set at 100%, is shown in the upper panels. MTT assays (Roche Diagnostics GmbH) from the same cultures are shown in the lower panels.