Multiple environmental and genetic factors influence skeletal muscle PGC-1α and PGC-1β gene expression in twins
J. Clin. Invest. Charlotte Ling, et al. 114:1518 doi:10.1172/JCI21889 [Go to this article.]

Figure 2
The effect of age on the association between skeletal muscle PGC-1α and PGC-1β mRNA expression and the PGC-1α Gly482Ser polymorphism. (A) PGC-1α and (B) PGC-1β mRNA expression, as measured by TaqMan Real-Time PCR (ABI 7900), in skeletal muscles of young and elderly twins before and after a hyperinsulinemic clamp, representing Gly/Gly (n = 38 and n = 29 for young and elderly, respectively) and Gly/Ser + Ser/Ser (n = 48 and n = 39 for young and elderly, respectively) PGC-1α-482 genotypes. The level of PGC-1α and PGC-1β transcripts are normalized to the mRNA level of endogenous cyclophilin A. The PGC-1α/cyclophilin A ratio and the PGC-1β/cyclophilin A ratio were calculated for each sample, and the ratios are presented in the figure. Results are expressed as the mean ± SEM. *P ≤ 0.05.