Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin
J. Clin. Invest. Kamal Rahmouni, et al. 114:652 doi:10.1172/JCI21737 [
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Figure 5Effects of PI3K and MAPK blockade on lumbar and BAT SNA responses to another stimulus, CRF. (
A) The PI3K inhibitors LY294002 (5 μg; ICV) and wortmannin (0.5 μg; ICV) have no effect on the lumbar sympathoactivation to CRF (5 μg; ICV). (
B) The MAPK inhibitors PD98059 (5 μg; ICV) and U0126 (7 μg; ICV) have no effect on the BAT sympathoactivation to CRF (5 μg; ICV). Data represent means ± SEM of 8–10 rats per group.
