Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin
J. Clin. Invest. Kamal Rahmouni, et al. 114:652 doi:10.1172/JCI21737 [
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Figure 4Effects of MAPK blockade on regional SNA responses to 500 mU of ICV insulin. (
A) Attenuated BAT SNA response to insulin in the presence of the MAPK inhibitors PD98059 (5 μg; ICV) and U0126 (7 μg; ICV). (
B) Blockade of SNA response to insulin with MAPK inhibitors is selective for BAT, as MAPK inhibitors have no effect on lumbar, adrenal, or renal SNA responses to insulin. Data represent means ± SEM of 8–18 animals per group. *
P < 0.001 versus the vehicle + insulin group.
