Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin
J. Clin. Invest. Kamal Rahmouni, et al. 114:652 doi:10.1172/JCI21737 [
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Figure 3Effects of PI3K blockade on regional SNA responses to 500 mU of ICV insulin. (
A) Attenuated lumbar SNA response to insulin in the presence of the PI3K inhibitors LY294002 (5 μg; ICV) and wortmannin (Wort; 0.5 μg; ICV). (
B) Blockade of SNA response to insulin with PI3K inhibitors is selective for the hindlimb, as PI3K inhibitors have no effect on BAT, adrenal, or renal SNA responses to insulin. Data represent means ± SEM of 8–18 animals per group. *
P < 0.001 versus the vehicle + insulin group.
