Scheme for the roles of intracellular proteolytic processes in regulating pathways for hepatic secretion of ApoB-containing lipoproteins and the modulating effects of saturated and n-3 fatty acids on these processes. Cotranslational lipidation of ApoB protects nascent particles from ERAD. Maturing particles can acquire choleteryl ester and be secreted as IDLs and larger LDLs or can fuse with a preformed lipid droplet to form larger VLDLs. Saturated fatty acids (SFAs) protect the smaller particles from PERPP, leading to increased secretion. Peroxidation products of n-3 polyunsaturated fatty acids (n-3 PUFA-ox), and perhaps also n-6 polyunsaturated fatty acids (not shown), increase PERPP, leading to decreased secretion of larger VLDLs and hence lower levels of their catabolic products, including small LDL particles.