Organization of the flavivirus genome and its resulting proteins and the location of the major targets of the immune response. The DENV genome is a single-stranded sense RNA with a single open reading frame (ORF; top). The ORF is translated as a single polyprotein (middle) that is cleaved by viral and host proteases to yield the ten viral proteins: the C protein; the M protein, which is synthesized as the larger precursor protein pre-M (pM); the major E glycoprotein; and seven NS proteins involved in viral replication among other functions (bottom). The strength of the antibody and T cell responses to individual viral proteins is indicated below.